detection of mouse cytomegalovirus in adenocarcinoma bearing razi/a mice: molecular and pathological studies

نویسندگان

f. abedini

m. moharrami

p. shams

m. eslampanah

h. adeldost

چکیده

despite a lot of research, the etiology and progression of breast cancer remain incompletely understood. recently, human cytomegalovirus (hcmv) was reported as a risk factor for breast cancer. the aim of this study was to know whether breast cancer could be caused by cytomegalovirus or not? in this experiment seventeen samples of razi/a mice with spontaneous breast cancer were being gathered from laboratory animals department. histopathology and polymerase chain reaction (pcr) tests were done on breast tissue samples. formalin-fixed tissue specimens were obtained from mouse normal breast tissues (n:17) and mouse mammary tumors (n:17). detection of mouse cytomegalovirus was done by the puc57-mck-2 plasmid. our histopathology data showed adenocarcinoma type b in mouse with mammary tumors. there was a significant difference between mice with spontaneous breast cancer and control by pearson chi-square (value: 17.000b and p=0.000). more research will be needed to determine the effect of cytomegalovirus on breast cancer.

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Detection of Mouse Cytomegalovirus in Adenocarcinoma Bearing Razi/A Mice: Molecular and Pathological Studies

Despite a lot of research, the etiology and progression of breast cancer remain incompletely understood. Recently, human cytomegalovirus (HCMV) was reported as a risk factor for breast cancer. The aim of this study was to know whether breast cancer could be caused by cytomegalovirus or not? In this experiment seventeen samples of RAZI/A mice with spontaneous breast cancer were being gathered fr...

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عنوان ژورنال:
archives of razi institute

ناشر: razi vaccine & serum research institute (rvsri)

ISSN 0365-3439

دوره 69

شماره 1 2016

میزبانی شده توسط پلتفرم ابری doprax.com

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